Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.58 |
| ▸ | CTSS | P25774 | 10/20 | 0.51 |
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183186 | 1.00 | CTSK (0.58) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL6183557 | 0.89 | CTSK (0.58) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL6183695 | 0.85 | CTSK (0.75) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6183984 | 0.80 | CTSL (0.66) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6182938 | 0.80 | CTSL (0.64) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6183050 | 0.79 | CTSK (0.70) | CTSKCTSSCTSLCTSB | |
| SCHEMBL22500377 | 0.78 | NPC1 (0.66) | CTSKALDH1A1LMNAMAPTATM | |
| SCHEMBL22500568 | 0.78 | NPC1 (0.66) | CTSKALDH1A1LMNAMAPTATM | |
| SCHEMBL22500278 | 0.76 | MAPT (0.56) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL22501106 | 0.76 | MAPT (0.67) | CTSKALDH1A1LMNAMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161415-B1 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6593327-B2 | N-cyanomethyl amides which are cysteine protease inhibitors; treating osteoporosis; mixtures with bisphosphonates | AXYS PHARMACEUTICALS, INC. | 2003-07-15 | — | — | US | disclosed |
| US-6476026-B1 | Compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |