Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 14/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14414271 | 0.77 | ITGB2 (0.52) | NOTUMCCNCCDK8 | |
| SCHEMBL20080888 | 0.77 | NOTUM (0.58) | NOTUMDPP4 | |
| SCHEMBL29141955 | 0.76 | NOTUM (0.64) | NOTUMDPP4 | |
| SCHEMBL4169504 | 0.76 | NPY5R (0.53) | NOTUMNPY5R | |
| SCHEMBL3805648 | 0.74 | NOTUM (0.61) | NOTUM | |
| SCHEMBL1409621 | 0.74 | NOTUM (0.68) | NOTUMDPP4 | |
| SCHEMBL21434104 | 0.73 | SMO (0.49) | — | |
| SCHEMBL28234009 | 0.73 | NOTUM (0.67) | NOTUMDPP4 | |
| SCHEMBL13724538 | 0.73 | GFER (0.57) | EPHX2 | |
| SCHEMBL22542098 | 0.73 | DRD2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |