Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 9/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163471 | 0.85 | FFAR1 (0.46) | P2RX3FFAR1LOXL2LOXACACB | |
| SCHEMBL2145724 | 0.83 | FFAR1 (0.47) | P2RX3FFAR1LOXL2LOXOPRM1 | |
| SCHEMBL2427347 | 0.80 | SMN1; SMN2 (0.46) | P2RX3HTTSMN1; SMN2 | |
| SCHEMBL20239263 | 0.80 | P2RX3 (0.44) | P2RX3FFAR1LOXL2LOXACACB | |
| SCHEMBL18049218 | 0.80 | LOXL2 (0.53) | P2RX3FFAR1LOXL2LOXACACB | |
| SCHEMBL18249748 | 0.78 | P2RX3 (0.47) | P2RX3FFAR1LOXL2ACACBOPRM1 | |
| SCHEMBL20239266 | 0.76 | FFAR1 (0.52) | P2RX3FFAR1LOXL2ACACBOPRM1 | |
| SCHEMBL28895924 | 0.74 | P2RX3 (0.41) | P2RX3FFAR1LOXL2 | |
| SCHEMBL3158059 | 0.73 | LOXL2 (0.44) | P2RX3FFAR1LOXL2LOXACACB | |
| SCHEMBL3173384 | 0.73 | MAP4K4 (0.42) | P2RX3FFAR1LOXL2LOXACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |