Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 13/20 | 0.49 |
| ▸ | PPARD | Q03181 | 8/20 | 0.49 |
| ▸ | PPARG | P37231 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186389 | 0.87 | ALDH1A1 (0.52) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL4807448 | 0.85 | MAPT (0.69) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL5528374 | 0.85 | ALDH1A1 (0.45) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL5899944 | 0.83 | KDM4E (0.55) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL3841396 | 0.81 | ALDH1A1 (0.52) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL14015121 | 0.81 | KDM4E (0.53) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL981341 | 0.80 | SMN1; SMN2 (0.71) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL10266315 | 0.80 | ALDH1A1 (0.45) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL4807401 | 0.80 | MAPT (0.47) | ALDH1A1NPC1GAAMAPTKDM4E | |
| SCHEMBL4809764 | 0.80 | MAPT (0.74) | ALDH1A1NPC1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349843-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | SMITHKLINE BEECHAM CORP (US) | 2005-04-20 | — | — | EP | disclosed |