Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815176 | 0.91 | ADRA1A (0.53) | ADRA1AADRA2AKMT2AMEN1CYP2D6 | |
| SCHEMBL4504292 | 0.85 | IDO1 (0.51) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL17414457 | 0.81 | KLK7 (0.55) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL4493891 | 0.80 | ACP3 (0.57) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL30943709 | 0.77 | ADRA2A (0.57) | ADRA1AADRA2AKMT2AMEN1CYP2D6 | |
| SCHEMBL8806213 | 0.77 | ADRA2A (0.57) | ADRA1AADRA2AKMT2AMEN1CYP2D6 | |
| SCHEMBL15643615 | 0.76 | KMT2A (0.52) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL6755543 | 0.75 | KMT2A (0.50) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL4670011 | 0.75 | CYP2D6 (0.56) | ADRA1AADRA2AKMT2AMEN1CYP2D6 | |
| SCHEMBL23414454 | 0.74 | ADRA1A (0.59) | ADRA1AADRA2AKMT2AMEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562919-A1 | PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004041793-A1 | PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-05-21 | — | — | WO | disclosed |