Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180880 | 0.93 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL7203427 | 0.85 | PTGS2 (0.42) | PTGS2PTGS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6169106 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6171000 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6170229 | 0.80 | PTGS2 (0.73) | PTGS2PTGS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL7201012 | 0.80 | PTGS2 (0.40) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6169956 | 0.79 | PTGS2 (0.77) | PTGS2PTGS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8161932 | 0.79 | PTGS2 (0.36) | PTGS2PTGS1 | |
| SCHEMBL6169510 | 0.78 | PTGS2 (0.73) | PTGS2PTGS1KDM4EALDH1A1POLB | |
| SCHEMBL6170742 | 0.77 | PTGS2 (0.73) | PTGS2PTGS1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |