Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1932268 | 0.87 | FFAR1 (0.52) | FFAR1FFAR4AKR1B1KEAP1CA1 | |
| SCHEMBL4030930 | 0.82 | CHEK1 (0.42) | FFAR1FFAR4S1PR1 | |
| SCHEMBL4022687 | 0.82 | RAB9A (0.46) | — | |
| SCHEMBL4715830 | 0.81 | S1PR1 (0.58) | FFAR1FFAR4AKR1B1KEAP1SLC22A12 | |
| SCHEMBL31230431 | 0.80 | KDM4E (0.42) | CA1CA2 | |
| SCHEMBL11685559 | 0.80 | KDM4E (0.42) | CA1CA2 | |
| SCHEMBL1002974 | 0.79 | FFAR1 (0.53) | FFAR1FFAR4KEAP1CA1CA2 | |
| SCHEMBL3352567 | 0.79 | FFAR1 (0.53) | FFAR1FFAR4AKR1B1KEAP1CA1 | |
| SCHEMBL23077756 | 0.78 | CYP1A2 (0.49) | FFAR1FFAR4S1PR1 | |
| SCHEMBL8385915 | 0.78 | MAOB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |