Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.52 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | ABL2 | P42684 | 7/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.46 |
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182185 | 0.85 | ABL1 (0.69) | ABL1SRCABL2EGFRMAP2K1 | |
| SCHEMBL7002867 | 0.84 | MAP2K1 (0.64) | SRCMAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL6188532 | 0.79 | SRC (0.73) | ABL1SRCABL2 | |
| SCHEMBL6183868 | 0.79 | SRC (0.74) | ABL1SRCABL2 | |
| SCHEMBL6382824 | 0.78 | MAP2K1 (0.68) | SRCEGFRMAP2K1RAF1MAPK3 | |
| SCHEMBL7001258 | 0.77 | MAP2K1 (0.57) | MAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL6184215 | 0.77 | SRC (0.73) | ABL1SRCABL2 | |
| SCHEMBL6183312 | 0.77 | SRC (0.73) | ABL1SRCABL2EGFR | |
| SCHEMBL6183229 | 0.76 | MAP2K1 (0.57) | SRCMAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL28909732 | 0.76 | EGFR (0.70) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499594-B1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES | WYETH CORP (US) | 2005-08-17 | — | — | EP | claimed |