Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.57 |
| ▸ | RAF1 | P04049 | 10/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382824 | 0.82 | MAP2K1 (0.68) | MAP2K1RAF1SRCMAPK3MAPK1 | |
| SCHEMBL6182253 | 0.82 | MAP2K1 (0.73) | MAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL5256805 | 0.79 | MAP2K1 (0.66) | MAP2K1RAF1SRCMAPK3MAPK1 | |
| SCHEMBL7001258 | 0.77 | MAP2K1 (0.57) | MAP2K1RAF1MAPK3MAPK1PRKCQ | |
| SCHEMBL6184752 | 0.76 | ABL1 (0.52) | MAP2K1RAF1SRCMAPK3MAPK1 | |
| SCHEMBL7000639 | 0.74 | MAP2K1 (0.53) | MAP2K1RAF1SRCMAPK3MAPK1 | |
| SCHEMBL6384883 | 0.74 | MAP2K1 (0.71) | MAP2K1RAF1SRCPRKCQ | |
| SCHEMBL5253282 | 0.74 | MAP2K1 (0.69) | MAP2K1RAF1SRCMAPK13MAP3K8 | |
| SCHEMBL25920182 | 0.72 | MAP2K1 (0.85) | MAP2K1RAF1SRCMAPK3MAPK1 | |
| SCHEMBL7000844 | 0.72 | MAP2K1 (0.67) | MAP2K1RAF1SRCMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499594-B1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ONE CARBONITRILES | WYETH CORP (US) | 2005-08-17 | — | — | EP | claimed |