Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ADA | P00813 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858266 | 0.84 | HSP90AA1 (0.40) | ADADDB1CRBNALDH1A1L3MBTL1 | |
| SCHEMBL7477788 | 0.83 | ADA (0.43) | KMT2AMEN1ADADDB1CRBN | |
| SCHEMBL7352721 | 0.83 | TRPM5 (0.41) | KMT2AMEN1ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL7350749 | 0.78 | ASAH1 (0.38) | KMT2AMEN1ALDH1A1HSD17B10ADORA2A | |
| SCHEMBL9791225 | 0.76 | KMT2A (0.60) | KMT2AMEN1ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL11216414 | 0.73 | KMT2A (0.48) | KMT2AMEN1ALDH1A1CFTRHSD17B10 | |
| SCHEMBL6189505 | 0.72 | GLO1 (0.38) | — | |
| SCHEMBL358722 | 0.71 | DPP4 (0.44) | ADADDB1CRBNALDH1A1HSD17B10 | |
| SCHEMBL24499272 | 0.70 | ADA (0.40) | ADADDB1CRBNHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL6118670 | 0.69 | DPP4 (0.43) | ADADDB1CRBNALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |