Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30633255 | 0.81 | POLB (0.52) | GLAPOLBKMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL21571032 | 0.80 | POLB (0.51) | GLAPOLBKMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL21571033 | 0.80 | POLB (0.51) | GLAPOLBKMT2AHPGDALDH1A1 | |
| SCHEMBL5470309 | 0.72 | GLA (0.59) | GLAPOLBKMT2AHPGDALDH1A1 | |
| SCHEMBL1379287 | 0.72 | KMT2A (0.42) | KMT2ASMN1; SMN2 | |
| SCHEMBL5193941 | 0.72 | POLB (0.57) | POLBHPGDALDH1A1TSHRKDM4E | |
| SCHEMBL21579620 | 0.72 | MAPT (0.47) | GLAPOLBKMT2AHPGDALDH1A1 | |
| SCHEMBL26016585 | 0.72 | F12 (0.56) | — | |
| Hydrochloric Acid SCHEMBL21571265 | 0.71 | MAPT (0.46) | GLAPOLBKMT2AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL21571269 | 0.71 | MAPT (0.46) | GLAPOLBKMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |