Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380848 | 0.81 | CACNA2D1 (0.51) | KMT2A | |
| SCHEMBL5193941 | 0.76 | POLB (0.57) | NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL13873879 | 0.73 | EPHX2 (0.60) | KMT2ATAAR1NPC1RAB9AEPHX2 | |
| SCHEMBL20116677 | 0.72 | TAAR1 (0.54) | KMT2ATAAR1NPC1RAB9AEPHX2 | |
| SCHEMBL6185437 | 0.72 | GLA (0.49) | KMT2ASMN1; SMN2 | |
| SCHEMBL13873727 | 0.71 | TAAR1 (0.47) | KMT2ATAAR1NPC1RAB9AEPHX2 | |
| SCHEMBL30743851 | 0.71 | AGTR2 (0.52) | KMT2ASMN1; SMN2 | |
| SCHEMBL13873847 | 0.70 | CYP2C9 (0.54) | TAAR1NPC1RAB9AEPHX2TP53 | |
| SCHEMBL5635599 | 0.70 | LMNA (0.41) | KMT2ATP53TPSAB1 | |
| SCHEMBL21611301 | 0.70 | ALDH1A1 (0.60) | TAAR1NPC1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4825664-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |