Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5993906 | 0.84 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3CYP2D6GPR119 | |
| SCHEMBL3645098 | 0.74 | MEN1 (0.56) | SLC6A4SLC6A2GPR119SMN1; SMN2JAK2 | |
| SCHEMBL4485498 | 0.73 | SLC6A2 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL6183532 | 0.72 | SLC6A2 (0.60) | SLC6A4SLC6A2SLC6A3CYP2D6GPR119 | |
| Cadaverine Tartrate SCHEMBL5995304 | 0.72 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5995080 | 0.71 | SLC6A4 (0.85) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5997497 | 0.70 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3GPR119HTT | |
| Fumaric Acid SCHEMBL5994167 | 0.69 | SLC6A2 (0.70) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 | |
| Fumaric Acid SCHEMBL5994164 | 0.69 | SLC6A2 (0.70) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5511565 | 0.68 | SLC6A4 (0.63) | SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569905-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052858-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |