Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.60 |
| ▸ | NOS1 | P29475 | 6/20 | 0.45 |
| ▸ | NOS2 | P35228 | 6/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5996682 | 0.87 | SLC6A2 (0.59) | SLC6A2SLC6A4NOS1NOS2GPR119 | |
| SCHEMBL3645098 | 0.77 | MEN1 (0.56) | SLC6A2SLC6A4CYP2C9GPR119 | |
| SCHEMBL5995922 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4NOS1NOS2SLC6A3 | |
| SCHEMBL3914840 | 0.74 | NOS2 (0.47) | NOS1NOS2 | |
| Fumaric Acid SCHEMBL5993894 | 0.74 | SLC6A2 (1.00) | SLC6A2SLC6A4NOS1NOS2SLC6A3 | |
| SCHEMBL6185559 | 0.72 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6GPR119 | |
| SCHEMBL5993914 | 0.71 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3GPR119 | |
| SCHEMBL5992970 | 0.71 | GPR119 (0.46) | GPR119 | |
| Acetic Acid SCHEMBL5993263 | 0.69 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3GPR119 | |
| SCHEMBL6205072 | 0.69 | SLC6A4 (0.61) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569905-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052858-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |