Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | CDK1 | P06493 | 4/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560834 | 0.85 | EGFR (0.57) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187995 | 0.84 | EGFR (0.66) | RAB9ANPC1EGFRCDK1SRC | |
| SCHEMBL8123474 | 0.81 | EGFR (0.74) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189468 | 0.79 | EGFR (0.61) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188550 | 0.79 | EGFR (0.62) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188036 | 0.79 | EGFR (0.64) | RAB9ANPC1EGFRCDK1SRC | |
| SCHEMBL5782958 | 0.77 | RAB9A (0.85) | RAB9ACCR2NPC1MAOBSMN1; SMN2 | |
| SCHEMBL8115748 | 0.77 | EGFR (0.77) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6190220 | 0.77 | EGFR (0.57) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187901 | 0.76 | EGFR (0.61) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |