Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705572 | 0.84 | MEN1 (0.59) | KDM4EKMT2AMEN1POLB | |
| SCHEMBL14198699 | 0.82 | MAPT (0.67) | KDM4EKMT2AMEN1POLB | |
| SCHEMBL3696610 | 0.81 | MEN1 (0.57) | KDM4EKMT2AMEN1POLBHRH3 | |
| SCHEMBL3692233 | 0.81 | MEN1 (0.61) | KDM4EKMT2AMEN1POLB | |
| SCHEMBL13285816 | 0.80 | KDM4E (0.72) | KDM4EKMT2AMEN1HRH3L3MBTL1 | |
| SCHEMBL8325191 | 0.80 | MEN1 (0.57) | KDM4EKMT2AMEN1POLB | |
| SCHEMBL27549340 | 0.78 | KDM4E (0.76) | KDM4EKMT2AMEN1 | |
| SCHEMBL30291085 | 0.77 | ALDH1A1 (0.66) | KDM4EHRH3 | |
| SCHEMBL2447400 | 0.77 | GAA (0.72) | KDM4EKMT2AMEN1HRH3L3MBTL1 | |
| SCHEMBL27569115 | 0.77 | KDM4E (0.74) | KDM4EKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |