Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168608 | 0.83 | RIPK1 (0.46) | PDE4BPOLBRXFP1RIPK1PARP1 | |
| SCHEMBL6169312 | 0.78 | PDE4B (0.65) | PDE4BPARP1SMN1; SMN2TP53 | |
| SCHEMBL4058811 | 0.78 | PDE4B (0.70) | PDE4BPOLBPARP1SMN1; SMN2MAPT | |
| SCHEMBL4706418 | 0.78 | PDE4B (0.60) | PDE4BPOLBPARP1CYP3A4CYP2C9 | |
| SCHEMBL4708521 | 0.78 | PDE4B (0.47) | PDE4BRXFP1PARP1CYP3A4CYP2C9 | |
| SCHEMBL4707672 | 0.78 | PDE4B (0.47) | PDE4BPOLBRXFP1RIPK1SMN1; SMN2 | |
| SCHEMBL4706455 | 0.78 | RIPK1 (0.51) | PDE4BPOLBRXFP1RIPK1PARP1 | |
| SCHEMBL4705746 | 0.77 | PDE4B (0.72) | PDE4BSMN1; SMN2MAPTTP53ACHE | |
| SCHEMBL4708479 | 0.76 | PDE4B (0.58) | PDE4BPOLBPARP1SMN1; SMN2MAPT | |
| SCHEMBL4708634 | 0.76 | PDE4B (0.51) | PDE4BRXFP1RIPK1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |