Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.62 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183998 | 0.85 | OPRM1 (0.61) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL23384015 | 0.81 | OPRM1 (0.71) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL10389866 | 0.78 | OPRM1 (0.67) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL31557718 | 0.78 | OPRM1 (0.64) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL2588266 | 0.76 | ALDH1A1 (0.73) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL4815044 | 0.75 | ALDH1A1 (0.67) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL8046465 | 0.75 | ALDH1A1 (0.67) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL1660644 | 0.75 | OPRM1 (0.61) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL6831189 | 0.75 | OPRM1 (0.61) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 | |
| SCHEMBL3079753 | 0.73 | OPRM1 (0.54) | OPRM1OPRK1OPRL1OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |