Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186265 | 1.00 | CTSK (0.40) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6185005 | 0.91 | F10 (0.41) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6185000 | 0.91 | F10 (0.41) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6406102 | 0.88 | MEN1 (0.39) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6189089 | 0.87 | F10 (0.40) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6266810 | 0.86 | CTSL (0.50) | CTSKCTSLCTSSCTSBJAK2 | |
| SCHEMBL6266806 | 0.86 | CTSL (0.50) | CTSKCTSLCTSSCTSBJAK2 | |
| SCHEMBL6190773 | 0.80 | USP30 (0.42) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6190774 | 0.80 | USP30 (0.42) | CTSKCTSLCTSSCDK2MEN1 | |
| SCHEMBL6208313 | 0.78 | CTSL (0.53) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539725-A1 | 3-(3,5-DISUBSTITUTED-4-HYDROXYPHENYL)PROPIONAMIDE DERIVATIVES AS CATHEPSIN B INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004026851-A1 | 3-(3,5-DISUBSTITUTED-4-HYDROXYPHENYL)PROPIONAMIDE DERIVATIVES AS CATHEPSIN B INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-04-01 | — | — | WO | disclosed |