Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15330574 | 1.00 | KLK1 (0.57) | KLK1CYP3A4ALDH1A1MIFTSHR | |
| SCHEMBL8293263 | 0.93 | CTRB1 (0.54) | CYP3A4ALDH1A1TSHRMAPTCTRB1 | |
| SCHEMBL29951738 | 0.82 | CTRB1 (0.49) | KLK1CYP3A4ALDH1A1TSHRMAPT | |
| SCHEMBL22811058 | 0.81 | LMNA (0.51) | CYP3A4ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL14067230 | 0.80 | CYP3A4 (0.54) | CYP3A4ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL13721922 | 0.80 | ATM (0.63) | KLK1CYP3A4TSHRCTRB1LMNA | |
| SCHEMBL5742261 | 0.80 | ATM (0.67) | KLK1CYP3A4ALDH1A1MIFMAPT | |
| SCHEMBL13721804 | 0.80 | ATM (0.63) | KLK1CYP3A4TSHRCTRB1LMNA | |
| SCHEMBL5742255 | 0.80 | ATM (0.67) | KLK1CYP3A4ALDH1A1MIFMAPT | |
| SCHEMBL17765000 | 0.80 | ATM (0.67) | KLK1CYP3A4ALDH1A1MIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521742-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005247-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |