⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998150 | 0.82 | — | — | |
| SCHEMBL1650778 | 0.82 | — | — | |
| SCHEMBL756341 | 0.82 | — | — | |
| SCHEMBL17224577 | 0.80 | CYP2D6 (0.39) | — | |
| SCHEMBL890128 | 0.78 | — | — | |
| SCHEMBL12646126 | 0.78 | — | — | |
| SCHEMBL890097 | 0.78 | — | — | |
| SCHEMBL21946036 | 0.78 | POLB (0.33) | — | |
| SCHEMBL5870467 | 0.78 | KMT2A (0.44) | — | |
| SCHEMBL3135120 | 0.78 | KMT2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010080-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-09-27 | — | — | EP | claimed |
| EP-1565461-A2 | ANTIBACTERIAL SUBSTITUTED CYANOMETHYL(ENE)PIPERIDINOPHENYL OXAZOLIDINONES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Patel, Mahesh V. (IN) | 2005-08-24 | — | — | EP | claimed |
| WO-2004007489-A2 | ANTIBACTERIAL SUBSTITUTED CYANOMETHYL (ENE) PIPERIDINOPHENYL OXAZOLIDINONES, PROCESS OR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WOCKHARDT LIMITED (IN) | 2004-01-22 | — | — | WO | claimed |
| EP-0844233-B1 | Process for preparing alpha-amino acid amides, alpha-amino acids and derivatives thereof | DSM NV (NL) | 2002-04-03 | — | — | EP | claimed |
| US-5977406-A | Process for preparing α-amino acid amides, α-amino acids and derivatives thereof | DSM NV (NL) | 1999-11-02 | — | — | US | claimed |
| EP-0844233-A1 | Process for preparing alpha-amino acid amides, alpha-amino acids and derivatives thereof | DSM N.V. (NL) | 1998-05-27 | — | — | EP | claimed |
| JP-10182574-A | — | — | None | — | — | JP | disclosed |
| US-20240158372-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. | 2024-05-16 | — | — | US | disclosed |
| US-11780826-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2023-10-10 | — | — | US | disclosed |
| CN-115867532-A | Inhibitors of APOL1 and uses thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20220281850-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. | 2022-09-08 | — | — | US | disclosed |
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| US-11254658-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2022-02-22 | — | — | US | disclosed |
| CN-101747287-A | 2-oxo-1,3-O-aza-cyclopentane-4-carboxamide derivative and application thereof in preparation of immunosuppressant | INST PHARM & TOXICOLOGY AMMS | 2010-06-23 | — | — | CN | disclosed |
| EP-0844233-B1 | Process for preparing alpha-amino acid amides, alpha-amino acids and derivatives thereof | DSM NV (NL) | 2002-04-03 | — | — | EP | disclosed |
| US-5977406-A | Process for preparing α-amino acid amides, α-amino acids and derivatives thereof | DSM NV (NL) | 1999-11-02 | — | — | US | disclosed |
| US-5977406-A | Process for preparing α-amino acid amides, α-amino acids and derivatives thereof | DSM NV (NL) | 1999-11-02 | — | — | US | disclosed |
| JP-H10182574-A | PREPARATION OF ALPHA-AMINO ACID AMIDE, ALPHA-AMINO ACID AND DERIVATIVE THEREOF | DSM NV | 1998-07-07 | — | — | JP | disclosed |
| EP-0844233-A1 | Process for preparing alpha-amino acid amides, alpha-amino acids and derivatives thereof | DSM N.V. (NL) | 1998-05-27 | — | — | EP | disclosed |
| EP-0844233-A1 | Process for preparing alpha-amino acid amides, alpha-amino acids and derivatives thereof | DSM N.V. (NL) | 1998-05-27 | — | — | EP | disclosed |