Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186238 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2AATMTP53ALDH1A1 | |
| SCHEMBL6184990 | 0.79 | TSHR (0.49) | SMN1; SMN2KMT2AALDH1A1USP2TSHR | |
| SCHEMBL5683016 | 0.78 | POLB (0.54) | SMN1; SMN2KMT2ATP53ALDH1A1USP2 | |
| SCHEMBL14420673 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AATMTP53ALDH1A1 | |
| SCHEMBL6186684 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2AATMTP53ALDH1A1 | |
| SCHEMBL14095110 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2AATMTP53ALDH1A1 | |
| SCHEMBL6497029 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2KMT2ATP53ALDH1A1USP2 | |
| SCHEMBL6504267 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2KMT2ATP53ALDH1A1USP2 | |
| Hydrochloric Acid SCHEMBL6502821 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2KMT2ATP53ALDH1A1USP2 | |
| SCHEMBL5791691 | 0.72 | HCRTR2 (0.57) | SMN1; SMN2KMT2AALDH1A1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2005538968-A | — | — | 2005-12-22 | — | — | JP | claimed |
| EP-1517898-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | Zentaris GmbH (DE) | 2005-03-30 | — | — | EP | claimed |
| US-20040097734-A1 | Aryl- and heteroarylcarbonylpiperazines and their use for the treatment of benign and malignant oncoses | ZENTARIS GMBH (DE) | 2004-05-20 | — | — | US | claimed |
| WO-2004002965-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | ZENTARIS GMBH (DE) | 2004-01-08 | — | — | WO | claimed |
| EP-1517898-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | Zentaris GmbH (DE) | 2005-03-30 | — | — | EP | disclosed |
| US-20040097734-A1 | Aryl- and heteroarylcarbonylpiperazines and their use for the treatment of benign and malignant oncoses | ZENTARIS GMBH (DE) | 2004-05-20 | — | — | US | disclosed |
| WO-2004002965-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | ZENTARIS GMBH (DE) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097734-A1 | Aryl- and heteroarylcarbonylpiperazines and their use for the treatment of benign and malignant oncoses | VHL, MYC, HCCS | SMN1; SMN2 4262/4885KMT2A 1242/4885ATM 4267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.