Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027737 | 1.00 | BDKRB1 (0.42) | BDKRB1TDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL4027744 | 0.87 | BDKRB1 (0.43) | BDKRB1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4027527 | 0.87 | BDKRB1 (0.46) | BDKRB1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6186875 | 0.85 | BDKRB1 (0.57) | BDKRB1TDP1HPGDRAB9ANPC1 | |
| SCHEMBL4027530 | 0.83 | BDKRB1 (0.45) | BDKRB1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4040824 | 0.81 | BDKRB1 (0.48) | BDKRB1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4031286 | 0.76 | BDKRB1 (0.73) | BDKRB1 | |
| SCHEMBL4032602 | 0.76 | BDKRB1 (0.54) | BDKRB1RAB9AALDH1A1HTT | |
| SCHEMBL4351895 | 0.74 | BDKRB1 (0.61) | BDKRB1TDP1HPGDTP53 | |
| SCHEMBL4036660 | 0.74 | BDKRB1 (0.74) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521744-A1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003106428-A1 | NOVEL ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS THERAPEUTIC AGENTS | LABORATOIRES FOURNIER SA (FR) | 2003-12-24 | — | — | WO | disclosed |