Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27509606 | 0.85 | BACE1 (0.53) | BACE1TDP1ALDH1A1HSD17B10SLC6A2 | |
| SCHEMBL3786057 | 0.85 | ALDH1A1 (0.50) | BACE1ALDH1A1HSD17B10SLC6A2SLC6A4 | |
| SCHEMBL3783312 | 0.81 | CSNK2A1 (0.65) | BACE1ALDH1A1HSD17B10CSNK2A1FOLH1 | |
| SCHEMBL98234 | 0.80 | CYP1A2 (0.56) | BACE1HSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL6011376 | 0.80 | MAP4K4 (0.45) | BACE1TDP1CYP4F2CYP4A11ACMSD | |
| SCHEMBL2865401 | 0.79 | TDP1 (0.50) | BACE1TDP1ALDH1A1CSNK2A1PDK2 | |
| SCHEMBL13957118 | 0.79 | CSNK2A1 (0.49) | BACE1ALDH1A1HSD17B10CSNK2A1ALOX5 | |
| SCHEMBL28171242 | 0.79 | ALDH1A1 (0.48) | BACE1ALDH1A1HSD17B10SLC6A2SLC6A4 | |
| SCHEMBL101148 | 0.79 | MAPT (0.54) | MAPTSMN1; SMN2 | |
| SCHEMBL10713778 | 0.79 | LMNA (0.56) | TDP1ALDH1A1HSD17B10KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542977-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | AstraZeneca AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004020415-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | disclosed |