Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187429 | 0.87 | HTR6 (0.65) | KMT2AHTR6MEN1LMNA | |
| SCHEMBL6186532 | 0.86 | HTR6 (0.64) | KMT2AHTR6MEN1 | |
| SCHEMBL8325887 | 0.86 | PDE4A (0.86) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6188091 | 0.85 | HTR6 (0.53) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6191274 | 0.85 | HTR6 (0.60) | KMT2AHTR6 | |
| SCHEMBL6187548 | 0.84 | HTR6 (0.61) | KMT2AHTR6 | |
| SCHEMBL17049204 | 0.81 | KMT2A (0.74) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6186261 | 0.81 | HTR6 (0.81) | KMT2AHTR6MEN1 | |
| SCHEMBL31058476 | 0.80 | KMT2A (0.69) | KMT2APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6188261 | 0.80 | HTR6 (0.79) | KMT2AHTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6316450-B1 | PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-13 | — | — | US | disclosed |