Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6191926 | 0.85 | HDAC1 (0.44) | HDAC1ALDH1A1BRD4SIRT2KDM4E | |
| SCHEMBL20946412 | 0.83 | MAPT (0.47) | MAPTALDH1A1HTTBRD4MEN1 | |
| SCHEMBL6191077 | 0.82 | KDM4E (0.50) | HDAC1MAPTALDH1A1BRD4KDM4E | |
| SCHEMBL6190237 | 0.82 | GAA (0.43) | HDAC1ALDH1A1BRD4KDM4EUSP2 | |
| SCHEMBL6188833 | 0.81 | HDAC1 (0.41) | HDAC1MAPTALDH1A1HTTBRD4 | |
| SCHEMBL31432063 | 0.77 | HDAC1 (0.44) | HDAC1MAPT | |
| SCHEMBL18398430 | 0.76 | MAPT (0.56) | HDAC1MAPTMEN1ALOX12KMT2A | |
| SCHEMBL13715437 | 0.74 | GLS (0.47) | HDAC1BRD4KMT2AGLSNR1H4 | |
| SCHEMBL19553568 | 0.73 | KCNA5 (0.45) | BRD4GLSNR1H4 | |
| SCHEMBL184425 | 0.73 | NR1H4 (0.61) | HDAC1BRD4KMT2AGLSNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979227-B1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2005-11-16 | — | — | EP | disclosed |
| US-6352982-B1 | TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-03-05 | — | — | US | disclosed |