Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184425 | 0.85 | NR1H4 (0.61) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL13135999 | 0.85 | GLS (0.50) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL31044413 | 0.84 | GLS (0.49) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL879574 | 0.84 | LOXL2 (0.56) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL24140014 | 0.83 | ALDH1A1 (0.49) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL20474743 | 0.83 | HDAC6 (0.56) | GLSNR1H4NAMPTHDAC1MMP13 | |
| SCHEMBL13765430 | 0.82 | GLS (0.47) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL21455594 | 0.82 | NR1H4 (0.48) | GLSNR1H4BRD4KDM4ASLC7A5 | |
| SCHEMBL6625943 | 0.82 | MMP13 (0.51) | GLSNR1H4KDM4ANAMPTHDAC1 | |
| SCHEMBL27945718 | 0.82 | GLS (0.47) | GLSNR1H4BRD4KDM4ASLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572783-B2 | Obesity; N-(1-benzyl-piperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-3-methyl-butyramide; modulators of ghrelin receptor (GHSR) | AMGEN INC. (US) | 2009-08-11 | — | — | US | disclosed |