Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469683 | 0.83 | CLK1 (0.55) | MAPTKDM4EALDH1A1NPSR1CLK1 | |
| SCHEMBL1795616 | 0.82 | KDM4E (0.55) | XDHSIRT2MAPTKDM4EALDH1A1 | |
| SCHEMBL8136810 | 0.81 | ALDH1A1 (0.47) | XDHSIRT2MAPTKDM4EALDH1A1 | |
| SCHEMBL8206423 | 0.80 | CYP1A2 (0.49) | XDHSIRT2MAPTKDM4EALDH1A1 | |
| SCHEMBL6187334 | 0.78 | FFAR1 (0.46) | SIRT2TSHR | |
| SCHEMBL12165513 | 0.75 | MAPT (0.46) | MAPTKDM4EALDH1A1CLK1DYRK1A | |
| SCHEMBL26732 | 0.74 | ABL1 (0.49) | KDM4EALDH1A1ABL1CLK1DYRK1A | |
| SCHEMBL28132 | 0.74 | KDM4E (0.54) | MAPTKDM4EALDH1A1CLK1DYRK1A | |
| SCHEMBL2472646 | 0.74 | KEAP1 (0.54) | MAPTKDM4EALDH1A1CLK1DYRK1A | |
| SCHEMBL3890176 | 0.74 | CA12 (0.41) | MAPTKDM4EALDH1A1CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979227-B1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2005-11-16 | — | — | EP | disclosed |
| US-6352982-B1 | TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-03-05 | — | — | US | disclosed |