Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRR | Q9GZT4 | 2/20 | 0.49 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 6/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479459 | 0.88 | EPHX1 (0.62) | EPHX1TAAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL4950704 | 0.88 | EPHX1 (0.62) | EPHX1TAAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL4950924 | 0.88 | EPHX1 (0.62) | EPHX1TAAR1SLC6A2MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL28001158 | 0.86 | EPHX1 (0.60) | SRREPHX1TAAR1SLC6A2MAOA | |
| Iodide SCHEMBL28946993 | 0.86 | EPHX1 (0.60) | EPHX1TAAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL17413364 | 0.78 | TAAR1 (0.75) | TAAR1SLC6A2MAOASLC6A4SLC6A3 | |
| SCHEMBL9417738 | 0.78 | TAAR1 (0.75) | TAAR1SLC6A2MAOASLC6A4SLC6A3 | |
| SCHEMBL16389766 | 0.78 | SLC6A4 (0.44) | EPHX1TAAR1SLC6A4CYP2D6CYP1A2 | |
| SCHEMBL4075991 | 0.78 | TAAR1 (0.75) | TAAR1SLC6A2MAOASLC6A4SLC6A3 | |
| SCHEMBL22861986 | 0.77 | TAAR1 (0.56) | SRRPSAT1EPHX1IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542977-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | AstraZeneca AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004020415-A1 | 2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12. | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | disclosed |