Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480184 | 0.76 | MEN1 (0.57) | TSHRLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL6480068 | 0.74 | MEN1 (0.60) | TSHRLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL6482423 | 0.73 | TSHR (0.59) | TSHRLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL6480930 | 0.73 | ALDH1A1 (0.61) | TSHRLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL13888766 | 0.64 | PIN1 (0.54) | LMNAMEN1KMT2APOLBKDM2B | |
| SCHEMBL11877651 | 0.64 | KDM2B (0.61) | LMNAMEN1KMT2APOLBKDM2B | |
| SCHEMBL4609870 | 0.63 | PIN1 (0.59) | LMNAMEN1KMT2APOLBKDM2B | |
| SCHEMBL31465692 | 0.61 | MAPT (0.48) | TSHRMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2166462 | 0.61 | PIN1 (0.52) | TSHRLMNAKMT2APOLBKDM2B | |
| SCHEMBL31465676 | 0.60 | KDM4E (0.46) | TSHRMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |