Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256186 | 0.84 | RAB9A (0.53) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL28753356 | 0.83 | RAB9A (0.52) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL4266434 | 0.81 | HDAC6 (0.49) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL27628938 | 0.79 | HDAC6 (0.50) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL4266440 | 0.78 | HDAC6 (0.49) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL27628842 | 0.77 | AHR (0.43) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL13947009 | 0.77 | SMN1; SMN2 (0.53) | RAB9ASMN1; SMN2NPC1L3MBTL1LMNA | |
| SCHEMBL4263261 | 0.75 | SMN1; SMN2 (0.47) | RAB9ASMN1; SMN2NPC1HDAC6LMNA | |
| SCHEMBL31272572 | 0.72 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 | |
| SCHEMBL17834023 | 0.71 | ALOX5 (0.48) | RAB9ASMN1; SMN2NPC1HDAC6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1536784-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014366-A1 | HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |