Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.55 |
| ▸ | PGR | P06401 | 11/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979410 | 0.80 | PARP10 (0.55) | TDP2PGRPARP10PARP11DGAT1 | |
| SCHEMBL6192593 | 0.72 | PARP10 (0.64) | TDP2PGRPARP10PARP11ALOX5 | |
| SCHEMBL28355091 | 0.71 | TDP2 (0.47) | TDP2PARP10PARP11 | |
| SCHEMBL18010817 | 0.71 | TDP2 (1.00) | TDP2PGRPARP10PARP11 | |
| SCHEMBL6190707 | 0.71 | TDP2 (0.51) | TDP2PGRPARP10PARP11ALOX5 | |
| SCHEMBL4563338 | 0.70 | PARP10 (0.61) | TDP2PGRPARP10PARP11 | |
| SCHEMBL18085429 | 0.69 | TDP2 (0.52) | TDP2PGRPARP10PARP11 | |
| SCHEMBL8159245 | 0.68 | PARP10 (1.00) | TDP2PGRPARP10PARP11 | |
| SCHEMBL4418534 | 0.68 | PGR (1.00) | TDP2PGRPARP10PARP11PDK2 | |
| SCHEMBL6205926 | 0.67 | METAP1 (0.41) | TDP2PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183247-B1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA GMBH (DE) | 2005-05-25 | — | — | EP | disclosed |
| EP-1183247-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6329407-B1 | ANOREXOGENIC AGENTS | AVENTISPHARMA DEUTSCHLAND GMBH (DE) | 2001-12-11 | — | — | US | disclosed |
| US-6187801-B1 | 6-CHLORO-2-METHYL-8H-INDENO(1,2-D)-THIAZOLE HYDROCHLORIDE, FOR EXAMPLE; ADMINISTERING TO TREAT OBESITY, DIABETES; ANORECTICS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-02-13 | — | — | US | disclosed |
| WO-2000051997-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |