Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL75899 | 0.98 | TSHR (0.52) | TSHRALDH1A1LMNAAPEX1GLRA1 | |
| Glycinebetaine SCHEMBL18301505 | 0.95 | TSHR (0.50) | TSHRALDH1A1LMNAAPEX1GLRA1 | |
| Glycinebetaine SCHEMBL21084282 | 0.88 | TSHR (0.43) | TSHRALDH1A1LMNAAPEX1GLRA1 | |
| Glycinebetaine SCHEMBL285287 | 0.85 | — | — | |
| Glycinebetaine SCHEMBL4457941 | 0.85 | TSHR (0.50) | TSHRALDH1A1LMNAAPEX1CPT2 | |
| Glycinebetaine SCHEMBL4541516 | 0.85 | TSHR (0.40) | TSHRALDH1A1LMNAAPEX1GLRA1 | |
| Glycinebetaine SCHEMBL20298304 | 0.85 | TSHR (0.40) | TSHRALDH1A1LMNAAPEX1GLRA1 | |
| Glycinebetaine SCHEMBL6673018 | 0.83 | TSHR (0.50) | TSHRALDH1A1LMNAAPEX1CPT2 | |
| Glycinebetaine SCHEMBL7521843 | 0.83 | TSHR (0.43) | TSHRALDH1A1LMNAAPEX1CPT2 | |
| Glycinebetaine SCHEMBL13733441 | 0.83 | TSHR (0.50) | TSHRALDH1A1LMNAAPEX1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108633288-A | thermostable β -glucuronidase preparations | 综合微色谱系统有限责任公司 | 2018-10-09 | — | — | CN | claimed |
| US-20100330174-A1 | BETAINE COMPOSITIONS | BIO ETHIC SPRL. (BE) | 2010-12-30 | — | — | US | claimed |
| EP-1569692-B1 | Betaine and salicylic acid compositions | MESSADEK JALLAL (BE) | 2010-11-10 | — | — | EP | claimed |
| US-7780990-B2 | Combination therapeutic compositions and method of use | MESSADEK JALLAL | 2010-08-24 | — | — | US | claimed |
| US-20080031964-A1 | COMBINATION THERAPEUTIC COMPOSITIONS AND METHOD OF USE | MESSADEK JALLAL | 2008-02-07 | — | — | US | claimed |
| US-20060233877-A1 | Betaine compositions | BIO ETHIC SPRL. (BE) | 2006-10-19 | — | — | US | claimed |
| EP-1569692-A2 | BETAINE AND SALICYLIC ACID COMPOSITIONS | Messadek, Jallal (BE) | 2005-09-07 | — | — | EP | claimed |
| WO-2004049095-A2 | BETAINE AND SALICYLIC ACID COMPOSITIONS | MESSADEK JALLAL (BE) | 2004-06-10 | — | — | WO | claimed |
| CN-104936977-B | Microtubule-modifying compounds | 开普敦大学 | 2019-10-08 | — | — | CN | disclosed |
| CN-109789063-A | Personal Care Gels and Methods | 高露洁-棕榄公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109645110-A | Non- gel-type easy cleaning wax fruit composite preservative and preparation method thereof | 山东祥维斯生物科技股份有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-109527221-A | Saccharomycete base compound micro-ecological preparation containing Valine and preparation method thereof | 吕锋 | 2019-03-29 | — | — | CN | disclosed |
| CN-109476872-A | Material suit | 惠普发展公司，有限责任合伙企业 | 2019-03-15 | — | — | CN | disclosed |
| CN-108633288-A | thermostable β -glucuronidase preparations | 综合微色谱系统有限责任公司 | 2018-10-09 | — | — | CN | disclosed |
| US-20060128657-A1 | Selected betaines and their uses | MESSADEK JALLAL | 2006-06-15 | — | — | US | disclosed |
| EP-1660070-A2 | SELECTED BETAINES AND THEIR USES | Messadek, Jallal (BE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2006007671-A2 | THERAPEUTICALLY COMBINATIONS | MESSADEK JALLAL (BE) | 2006-01-26 | — | — | WO | disclosed |
| EP-1569692-A2 | BETAINE AND SALICYLIC ACID COMPOSITIONS | Messadek, Jallal (BE) | 2005-09-07 | — | — | EP | disclosed |
| WO-2005011645-A2 | SELECTED BETAINES AND THEIR USES | MESSADEK JALLAL (BE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2004049095-A2 | BETAINE AND SALICYLIC ACID COMPOSITIONS | MESSADEK JALLAL (BE) | 2004-06-10 | — | — | WO | disclosed |