Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320759 | 0.78 | KDM4E (0.48) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL5440065 | 0.77 | KDM4E (0.57) | KDM4ETSHRSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL5447141 | 0.74 | PDE5A (0.45) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL5434692 | 0.74 | KDM4E (0.56) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL5442836 | 0.74 | TP53 (0.44) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL1411115 | 0.73 | KDM4E (0.57) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL3225296 | 0.71 | KDM4E (0.74) | NOS1KDM4EHSD17B10MAPTMAPK1 | |
| SCHEMBL7057695 | 0.71 | KDM4E (0.62) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL6889649 | 0.70 | ADORA2B (0.69) | KDM4ETSHRSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL6885588 | 0.69 | MAPK1 (0.51) | KDM4ETSHRSMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193257-B1 | Compounds for ceramide-mediated signal transduction | UNIV CALIFORNIA (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-0986561-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6562819-B2 | Antiinflammatory agents; antiproliferative agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-13 | — | — | US | disclosed |
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-07 | — | — | US | disclosed |
| EP-0801568-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1193257-A2 | Compounds for ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6323201-B1 | ANTIINFLAMMATORY AGENTS, ANTIPROLIFERATION AGENTS AND ENZYME INHIBITORS OF PHOSPHODIESTERASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-11-27 | — | — | US | disclosed |
| EP-0986561-A4 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1091960-A1 | BIFUNCTIONAL ANTAGONISTS OF CYTOKINE-SENSITIVE PROTEIN KINASE ACTIVATION CASCADES AND METHODS FOR USE AS ANTI-INFLAMMATORY AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-0986561-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | The Regents of the University of California (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-2000000491-A1 | BIFUNCTIONAL ANTAGONISTS OF CYTOKINE-SENSITIVE PROTEIN KINASE ACTIVATION CASCADES AND METHODS FOR USE AS ANTI-INFLAMMATORY AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-01-06 | — | — | WO | disclosed |
| US-5843943-A | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-01 | — | — | US | disclosed |
| WO-1998052948-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-11-26 | — | — | WO | disclosed |
| EP-0801568-A4 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0801568-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996020710-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | SMPD1, CERT1, SMPD3 | NOS1 69/4885KDM4E 2809/4885TSHR 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.