Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.74 |
| ▸ | CBFB | Q13951 | 1/20 | 0.74 |
| ▸ | NOS1 | P29475 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.57 |
| ▸ | LIG1 | P18858 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10983379 | 0.88 | KDM4E (0.74) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL2209868 | 0.83 | ADORA3 (0.57) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL3444582 | 0.76 | NOS1 (0.62) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL10979871 | 0.76 | PIK3CG (0.68) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL8836341 | 0.73 | POLB (0.51) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL3444579 | 0.73 | NOS1 (1.00) | KDM4ENOS1RAB9AHSD17B10PIK3CG | |
| SCHEMBL11125582 | 0.71 | KDM4E (0.53) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL31350659 | 0.71 | FEN1 (0.56) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL7833902 | 0.71 | KDM4E (0.55) | KDM4EALDH1A1GAARUNX1CBFB | |
| SCHEMBL6192079 | 0.71 | NOS1 (0.52) | KDM4EALDH1A1GAARUNX1CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021897-A1 | NUCLEOSIDIC PHOSPHORAMIDITE CRYSTALLINE MATERIAL AND A PROCESS FOR PURIFYING THE SAME | MERCK SHARP & DOHME CORP. (US) | 2010-02-25 | — | — | WO | disclosed |
| US-7057062-B2 | Process for manufacturing purified phosphorodiamidite | ISIS PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1492800-A2 | PROCESS FOR MANUFACTURING PURIFIED PHOSPHORODIAMIDITE | ISIS PHARMACEUTICALS, INC. (US) | 2005-01-05 | — | — | EP | disclosed |
| US-20030225284-A1 | Process for manufacturing purified phosphorodiamidite | IONIS PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
| WO-2003087130-A2 | PROCESS FOR MANUFACTURING PURIFIED PHOSPHORODIAMIDITE | ISIS PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225284-A1 | Process for manufacturing purified phosphorodiamidite | PHOSPHO1, PNP, OSGEP | KDM4E 3888/4885ALDH1A1 4819/4885GAA 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.