Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28171235 | 0.88 | ALDH1A1 (0.32) | TSHRALDH1A1POLBSMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL28171965 | 0.87 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL6252891 | 0.83 | ALDH1A1 (0.34) | TSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28798967 | 0.83 | — | — | |
| SCHEMBL6252532 | 0.83 | TSHR (0.33) | TSHR | |
| SCHEMBL30393948 | 0.80 | TSHR (0.31) | TSHR | |
| SCHEMBL29673007 | 0.71 | SOAT1 (0.34) | TSHRFAAHMGLLALDH1A1POLB | |
| SCHEMBL4436164 | 0.71 | — | — | |
| SCHEMBL932027 | 0.71 | — | — | |
| SCHEMBL4771331 | 0.70 | TSHR (0.35) | TSHRMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116265467-B | Intermediate for synthesizing TYK2 inhibitor, and preparation method and application thereof | 成都科岭源医药技术有限公司 | 2025-04-18 | — | — | CN | disclosed |
| CN-116829562-B | Macrocyclic compound, pharmaceutical composition and application thereof | 深圳国顺康医药科技有限公司 | 2025-04-01 | — | — | CN | disclosed |
| CN-113527298-B | Macrocyclic lactam derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| US-20240270759-A1 | Preparation of SHP2 phosphatase inhibitors and its applications | YA THERAPEUTICS INC (CN) | 2024-08-15 | — | — | US | disclosed |
| CN-117886813-A | SHP2 phosphatase allosteric inhibitors | 药雅科技(上海)有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117756848-A | TH-302 derivative and preparation method thereof | 常州大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-113727984-B | Macrocyclic derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-112204029-B | Therapeutic compounds | 豪夫迈·罗氏有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-115052660-B | Substituted 7- (methylamino) pyrazolo [1,5-a ] pyrimidine-3-carboxamide derivatives | 伊莱利利公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2019233461-A1 | TROPOMYOSIN RECEPTOR KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏威凯尔医药科技有限公司 (CN) | 2019-12-12 | — | — | WO | disclosed |
| CN-109715165-A | Huge ring kinase inhibitor | TP生物医药公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-108473498-A | Pyrazolo [1,5a] pyrimidine derivatives as IRAK4 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-104910161-B | Pyrazolopyrimidine compound and method as JAK inhibitor | 健泰科生物技术公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-107735399-A | The big ring of chiral diaryl as the conditioning agent of protein kinase | TP生物医药公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-107108638-A | Piperidyl PyrazolopyrimidinonecGMP and application thereof | 拜耳制药股份公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-1771231-B | Calcium receptor modulating compounds and uses thereof | TAKEDA CHEMICAL INDUSTRIES LTD | 2011-05-25 | — | — | CN | disclosed |
| CN-1771231-A | Calcium receptor modulating compounds and uses thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-05-10 | — | — | CN | disclosed |
| EP-1511751-A1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS ANTIVIRAL AGENTS | Neogenesis Pharmaceuticals, Inc. (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003101993-A1 | PYRAZOLO` 1,5A! PYRIMIDINE COMPOUNDS AS ANTIVIRAL AGENTS | NEOGENESIS PHARMACEUTICALS, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270759-A1 | Preparation of SHP2 phosphatase inhibitors and its applications | PTPN2, PTPN22, PTPN5 | TSHR 988/4885MEN1 974/4885KMT2A 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.