Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080985 | 0.84 | JAK3 (0.47) | ALDH1A1RAB9ASMN1; SMN2JAK3TYK2 | |
| SCHEMBL1204172 | 0.82 | PIN1 (0.62) | PIN1SMN1; SMN2JAK3TYK2JAK2 | |
| SCHEMBL29549327 | 0.77 | PIN1 (0.51) | PIN1MAPTALDH1A1SMN1; SMN2LCK | |
| SCHEMBL22807430 | 0.77 | PIN1 (0.51) | PIN1MAPTALDH1A1SMN1; SMN2LCK | |
| SCHEMBL3811000 | 0.77 | PIN1 (0.58) | PIN1MAPTJAK3TYK2JAK2 | |
| SCHEMBL3807303 | 0.75 | PIN1 (0.53) | PIN1MAPTJAK3TYK2JAK2 | |
| SCHEMBL8298042 | 0.75 | PIN1 (0.58) | PIN1MAPTALDH1A1PTK2BGSK3B | |
| SCHEMBL3814860 | 0.75 | PIN1 (0.62) | PIN1MAPTJAK3TYK2JAK2 | |
| SCHEMBL6193447 | 0.75 | PRKCQ (0.53) | PIN1GSK3BDCLK1PRKD3MAP4K4 | |
| SCHEMBL16012501 | 0.75 | PIN1 (0.68) | PIN1MAPTSMN1; SMN2JAK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-A2 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074244-A2 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |