Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195265 | 0.87 | PTGIR (0.32) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7939254 | 0.84 | PLK4 (0.39) | PLK4CHEK1AURKADAPK3PRKD3 | |
| SCHEMBL6199867 | 0.77 | DRD4 (0.38) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6194117 | 0.77 | DRD4 (0.38) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6200590 | 0.77 | DRD4 (0.33) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195844 | 0.74 | HTR2C (0.34) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6199771 | 0.73 | MAPT (0.68) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6196095 | 0.72 | NOS3 (0.31) | NOS2 | |
| SCHEMBL6197590 | 0.72 | DRD4 (0.35) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6196951 | 0.71 | HTR2C (0.33) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |