Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7939226 | 0.85 | KDM4E (0.63) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6194576 | 0.80 | MAPT (0.64) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6199260 | 0.80 | KDM4E (0.44) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195101 | 0.76 | KDM4E (0.41) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6199018 | 0.74 | KDM4E (0.39) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195098 | 0.73 | PLK4 (0.40) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6196389 | 0.70 | DRD4 (0.38) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195969 | 0.68 | DRD4 (0.33) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6200590 | 0.68 | DRD4 (0.33) | MAPTKDM4EHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6199867 | 0.68 | DRD4 (0.38) | MAPTKDM4EHSD17B10TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| CN-1097054-C | Tricyclic pyrazol derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 2002-12-25 | — | — | CN | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |
| CN-1203234-A | Tricyclic pyrazol derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1998-12-30 | — | — | CN | disclosed |