Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193322 | 0.89 | HTR1A (0.45) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6198293 | 0.88 | DRD2 (0.43) | DRD2DRD4HTR1AHTR2AADRA1A | |
| SCHEMBL6193824 | 0.88 | DRD4 (0.43) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6194546 | 0.86 | DRD2 (0.46) | DRD2DRD4HTR1AHTR2AADRA1A | |
| SCHEMBL6192783 | 0.85 | HTR1A (0.48) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6193242 | 0.84 | DRD2 (0.46) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6194846 | 0.83 | HTR1A (0.40) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6211824 | 0.83 | DRD4 (0.49) | DRD2DRD4HTR1AADRA1AADRA1D | |
| SCHEMBL6192427 | 0.82 | HTR1A (0.39) | DRD2DRD4HTR1AHTR2AADRA1A | |
| SCHEMBL6192729 | 0.81 | MAPT (0.44) | DRD2DRD4MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432701-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS OF THE URINARY TRACT | RECORDATI IRELAND LTD (IE) | 2005-12-21 | — | — | EP | claimed |