Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196706 | 0.79 | ADRA1D (0.34) | ADRA1DADRA1AADRA1BKDM1ACACNA1F | |
| SCHEMBL6198367 | 0.78 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BALDH1A1RAB9A | |
| SCHEMBL6196834 | 0.76 | ADRA1D (0.51) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6198625 | 0.76 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL7674379 | 0.76 | ADRA1D (0.51) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6715316 | 0.76 | CACNA1F (0.44) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6193641 | 0.75 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL7162576 | 0.75 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6715576 | 0.73 | CACNA1F (0.48) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6772155 | 0.73 | CACNA1F (0.39) | ADRA1DADRA1AADRA1BALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |