Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 10/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198371 | 0.78 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6196703 | 0.78 | PTGS2 (0.36) | ADRA1DADRA1AADRA1BRAB9ASMN1; SMN2 | |
| SCHEMBL8555300 | 0.72 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6196706 | 0.67 | ADRA1D (0.34) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6198625 | 0.64 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL6193641 | 0.63 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BCACNA1FCACNA1D | |
| SCHEMBL30597073 | 0.62 | ALDH1A1 (0.68) | RAB9ASMN1; SMN2MEN1NPC1KMT2A | |
| SCHEMBL12309435 | 0.62 | ALDH1A1 (0.68) | RAB9ASMN1; SMN2MEN1NPC1KMT2A | |
| SCHEMBL7564445 | 0.61 | MGLL (0.39) | — | |
| SCHEMBL983419 | 0.60 | ALDH1A1 (0.62) | RAB9ASMN1; SMN2MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |