Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | AS3MT | Q9HBK9 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197245 | 0.90 | TSHR (0.50) | TSHRGAAAS3MTALDH1A1NR1I2 | |
| SCHEMBL6196159 | 0.85 | TSHR (0.52) | TSHRGAAAS3MTALDH1A1NR1I2 | |
| SCHEMBL3716061 | 0.79 | TSHR (0.43) | TSHRGAAAS3MTALDH1A1GHSR | |
| SCHEMBL20550869 | 0.79 | GAA (0.38) | TSHRGAAALDH1A1NR1I2AHR | |
| SCHEMBL20185362 | 0.78 | TSHR (0.51) | TSHRGAAGHSRPOLB | |
| SCHEMBL6196995 | 0.77 | PDE2A (0.50) | TSHRGAAALDH1A1GHSRHPGD | |
| SCHEMBL20500103 | 0.76 | CTSL (0.41) | TSHRGAAAS3MTGHSRHPGD | |
| SCHEMBL31194571 | 0.74 | TSHR (0.70) | TSHRGAAALDH1A1HPGDMAPK1 | |
| SCHEMBL20580884 | 0.72 | PDE2A (0.50) | TSHRGAAAS3MTALDH1A1GHSR | |
| SCHEMBL11546474 | 0.69 | TSHR (0.40) | TSHRGAAALDH1A1NR1I2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |