Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 1.00 |
| ▸ | GABRP | O00591 | 9/20 | 1.00 |
| ▸ | GABRD | O14764 | 9/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 9/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 9/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 9/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 9/20 | 1.00 |
| ▸ | GABRA5 | P31644 | 9/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 9/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 9/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 9/20 | 1.00 |
| ▸ | GABRA4 | P48169 | 9/20 | 1.00 |
| ▸ | GABRE | P78334 | 9/20 | 1.00 |
| ▸ | GABRA6 | Q16445 | 9/20 | 1.00 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 1.00 |
| ▸ | GABRG3 | Q99928 | 9/20 | 1.00 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950799 | 0.84 | GABRG2 (0.72) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3950470 | 0.82 | GABRG2 (0.69) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3960106 | 0.78 | GRM5 (0.62) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3954787 | 0.74 | GABRG2 (0.58) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2234693 | 0.70 | GABRG2 (0.54) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2233575 | 0.70 | GABRG2 (0.54) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6195949 | 0.70 | GRM5 (0.54) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9046799 | 0.65 | GABRG2 (0.48) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10569786 | 0.65 | GRM5 (0.77) | GRM5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10576549 | 0.65 | GABRA1 (1.00) | GRM5GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349839-B8 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-06-22 | — | — | EP | claimed |
| EP-1349839-B1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | EP | claimed |
| US-6706707-B2 | TREATMENT OR PREVENTION OF MGLUR5 RECEPTOR MEDIATED DISORDERS. | HOFFMAN-LA ROCHE INC. | 2004-03-16 | — | — | US | claimed |
| EP-1349839-A1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | claimed |
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | F.HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | US | claimed |
| WO-2002046166-A1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | claimed |
| US-6972299-B2 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | HOFFMANN-LA ROCHE INC. (US) | 2005-12-06 | — | — | US | disclosed |
| EP-1599204-A2 | SELECTIVE MGLU5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT | Recordati Ireland Limited (IE) | 2005-11-30 | — | — | EP | disclosed |
| US-6927232-B2 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | HOFFMAN-LA ROCHE INC. (US) | 2005-08-09 | — | — | US | disclosed |
| EP-1349839-B8 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-06-22 | — | — | EP | disclosed |
| US-20050131043-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | MUTEL VINCENT (FR) | 2005-06-16 | — | — | US | disclosed |
| EP-1349839-B1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | EP | disclosed |
| US-20040215284-A1 | Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists | RECORDATI S.A. | 2004-10-28 | — | — | US | disclosed |
| WO-2004067002-A2 | SELECTIVE mGlu5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT | RECORDATI IRELAND LIMITED (IE) | 2004-08-12 | — | — | WO | disclosed |
| US-6706707-B2 | TREATMENT OR PREVENTION OF MGLUR5 RECEPTOR MEDIATED DISORDERS. | HOFFMAN-LA ROCHE INC. | 2004-03-16 | — | — | US | disclosed |
| US-20030225070-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | MUTEL VINCENT (FR) | 2003-12-04 | — | — | US | disclosed |
| US-20030208082-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | MUTEL VINCENT (FR) | 2003-11-06 | — | — | US | disclosed |
| EP-1349839-A1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | F.HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | US | disclosed |
| WO-2002046166-A1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131043-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, GRM6 | GRM5 1/4885GABRP 205/4885GABRD 502/4885 |
| US-20030208082-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, GRM1 | GRM5 1/4885GABRP 104/4885GABRD 355/4885 |
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, GRM1 | GRM5 1/4885GABRP 104/4885GABRD 355/4885 |
| US-20030225070-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, HRH4 | GRM5 1/4885GABRP 100/4885GABRD 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.