SCHEMBL6197271

SCHEMBL6197271

Cn1ncc(Br)c1-c1cccc(NC(=O)Cc2ccccc2F)c1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 7/20 0.58
HTR2C P28335 5/20 0.46
ALDH1A1 P00352 1/20 0.46
RAB9A P51151 3/20 0.45
NPC1 O15118 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
ANO1 Q5XXA6 3/20 0.45
ELOVL1 Q9BW60 2/20 0.43
P2RY14 Q15391 3/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6197597 0.86 P2RY14 (0.58) HTR2AHTR2CALDH1A1SMN1; SMN2P2RY14
SCHEMBL6198737 0.84 HTR2A (0.58) HTR2AHTR2CALDH1A1RAB9ANPC1
SCHEMBL2960652 0.80 L3MBTL1 (0.64) HTR2AALDH1A1RAB9ANPC1SMN1; SMN2
SCHEMBL6199703 0.79 HTR2A (0.78) HTR2AHTR2C
SCHEMBL6670281 0.79 HTR2A (0.71) HTR2AHTR2CALDH1A1RAB9ANPC1
SCHEMBL6197966 0.79 HTR2A (0.62) HTR2AHTR2CRAB9ANPC1SMN1; SMN2
SCHEMBL6197988 0.78 P2RY14 (0.57) HTR2AHTR2CP2RY14
SCHEMBL6198945 0.78 L3MBTL1 (0.64) HTR2AHTR2CALDH1A1SMN1; SMN2
SCHEMBL6198605 0.78 HTR2A (0.76) HTR2AHTR2CALDH1A1P2RY14LMNA
SCHEMBL6200743 0.78 HTR2A (0.72) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1509505-A2 SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2005-03-02 EP claimed
WO-2003062206-A2 SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2003-07-31 WO claimed
EP-1509505-A2 SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2005-03-02 EP disclosed
WO-2003062206-A2 SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2003-07-31 WO disclosed