Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194946 | 0.85 | HTT (0.49) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL21082280 | 0.84 | MEN1 (0.64) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6196888 | 0.83 | HTT (0.48) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8849907 | 0.83 | HTT (0.46) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6195834 | 0.83 | HTT (0.47) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6197604 | 0.82 | MAPK1 (0.48) | HTTSMN1; SMN2MAPK1MTNR1AMAOB | |
| SCHEMBL6196490 | 0.82 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL27480829 | 0.81 | HTT (0.50) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6193627 | 0.81 | HTT (0.49) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6194653 | 0.81 | SPHK2 (0.48) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |