Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197397 | 0.82 | HTT (0.46) | MAPK1MTNR1AMTNR1BMAOBHTT | |
| SCHEMBL6195293 | 0.81 | KDM4E (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6197640 | 0.79 | KDM4E (0.46) | MAPK1KDM4ETP53CYP2D6HTT | |
| SCHEMBL6196471 | 0.79 | KDM4E (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL8850201 | 0.79 | FABP4 (0.40) | MAPK1KDM4ETP53CYP2D6HTT | |
| SCHEMBL6198182 | 0.78 | KMT2A (0.42) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6193890 | 0.78 | LMNA (0.46) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL27481986 | 0.77 | KMT2A (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6197536 | 0.76 | CYP2D6 (0.38) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL8850540 | 0.75 | TNF (0.52) | KDM4ETP53CYP2D6HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |