Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28583866 | 0.80 | ALOX15 (0.43) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL6590589 | 0.72 | ALDH1A1 (0.40) | AURKAPDE5APDE1APDE1BPDE3B | |
| SCHEMBL6589267 | 0.71 | NTRK1 (0.37) | MAP4K4NPC1 | |
| SCHEMBL3519078 | 0.71 | MCL1 (0.51) | AURKAPDE5APDE1APDE1BPDE3B | |
| SCHEMBL1849595 | 0.71 | NTRK1 (0.50) | AURKAMETAP2MAOAATAD2MAP4K4 | |
| SCHEMBL10969851 | 0.69 | AURKA (0.42) | AURKAPDE5APDE1APDE1BPDE3B | |
| SCHEMBL12776054 | 0.67 | PDE4B (0.39) | — | |
| SCHEMBL18901018 | 0.66 | DPP4 (0.44) | KDM4EALDH1A1HPGDLMNAMAPT | |
| SCHEMBL8123308 | 0.66 | MAP4K4 (0.45) | AURKAMETAP2MAOAPDPK1ATAD2 | |
| SCHEMBL21225043 | 0.66 | MAP2K4 (0.45) | METAP2MEN1ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| EP-1244632-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | Arena Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001029008-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | ARENA PHARMACEUTICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |