Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194117 | 0.76 | DRD4 (0.38) | DRD4DRD2 | |
| SCHEMBL6195098 | 0.71 | PLK4 (0.40) | DRD4DRD2CDK8 | |
| SCHEMBL6199867 | 0.71 | DRD4 (0.38) | DRD4DRD2 | |
| SCHEMBL6200590 | 0.71 | DRD4 (0.33) | DRD4DRD2 | |
| SCHEMBL6195844 | 0.71 | HTR2C (0.34) | DRD4DRD2 | |
| SCHEMBL6197590 | 0.69 | DRD4 (0.35) | DRD4DRD2 | |
| SCHEMBL6196389 | 0.66 | DRD4 (0.38) | DRD4DRD2 | |
| SCHEMBL6195101 | 0.66 | KDM4E (0.41) | DRD4DRD2 | |
| SCHEMBL6199260 | 0.64 | KDM4E (0.44) | DRD4DRD2 | |
| SCHEMBL6199771 | 0.62 | MAPT (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |