Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27894896 | 0.75 | KDM4E (0.57) | HTTATMALDH1A1MGLLL3MBTL1 | |
| SCHEMBL12974657 | 0.73 | EPHX1 (0.63) | HTTATMSMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL10244651 | 0.71 | HTT (0.51) | HTTATMSMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL2361098 | 0.71 | HTT (0.91) | HTTATMSMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL18274878 | 0.71 | SMN1; SMN2 (0.59) | KMT2AHTTATMSMN1; SMN2EPHX1 | |
| SCHEMBL14424482 | 0.70 | EPHX1 (0.63) | KMT2AHTTEPHX1ALDH1A1NPC1 | |
| SCHEMBL16347264 | 0.70 | HTT (0.62) | HTTATMSMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL11034317 | 0.69 | EPHX1 (0.84) | HTTEPHX1ALDH1A1EPHX2 | |
| SCHEMBL6438783 | 0.69 | EPHX1 (0.84) | HTTEPHX1ALDH1A1EPHX2 | |
| SCHEMBL11033138 | 0.69 | EPHX1 (0.84) | HTTEPHX1ALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047418-B1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2005-07-27 | — | — | EP | disclosed |
| US-3990879-A | SUBSTITUTED 1-THIADIAZOLYL-3-ARYL-UREAS | ELI LILLY AND COMPANY (US) | 1976-11-09 | — | — | US | disclosed |
| US-3990879-A | SUBSTITUTED 1-THIADIAZOLYL-3-ARYL-UREAS | ELI LILLY AND COMPANY (US) | 1976-11-09 | — | — | US | disclosed |